Cancer

Tumor-informed ctDNA as an objective marker for postoperative residual disease in epithelial ovarian cancer
Background
The most important predictor of prognosis in patients with high-grade serous ovarian cancer (HGSOC) is complete tumor …
Valentina Paspalj, Christoph Grimm, Magdalena Postl, Christina Viktoria Tauber, Nuria Segui, Christian Brueffer, Miguel Alcaide, Lucia Oton, Yilun Chen, Lao H. Saal, Gerda Hofstetter, Leonhard Muellauer, Mirjana Kessler, Fabian Trillsch
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Tumor-informed ctDNA as an objective marker for postoperative residual disease in epithelial ovarian cancer
Proteomic profiling reveals that ESR1 mutations enhance cyclin-dependent kinase signaling
Three quarters of all breast cancers express the estrogen receptor (ER, ESR1 gene), which promotes tumor growth and constitutes a …
Tommaso De Marchi, Chun-Fui Lai, Georgia M. Simmons, Isabella Goldsbrough, Alison Harrod, Thai Lam, Lakjaya Buluwela, Sven Kjellström, Christian Brueffer, Lao H. Saal, Johan Malmström, Simak Ali, Emma Niméus
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Proteomic profiling reveals that ESR1 mutations enhance cyclin-dependent kinase signaling
Digital PCR quantification of ultrahigh ERBB2 copy number identifies poor breast cancer survival after trastuzumab
HER2/ERBB2 evaluation is necessary for treatment decision-making in breast cancer (BC), however current methods have limitations and …
Pei Meng, Hina Dalal, Yilun Chen, Christian Brueffer, Sergii Gladchuk, Miguel Alcaide, Anna Ehinger, Lao H. Saal
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Digital PCR quantification of ultrahigh ERBB2 copy number identifies poor breast cancer survival after trastuzumab
Preoperative ctDNA Levels are Associated with Poor Overall Survival in Patients with Ovarian Cancer
Background/Aim
Circulating tumor DNA (ctDNA), which is shed from cancer cells into the bloodstream, offers a potential minimally …
Arturas Dobilas, Yilun Chen, Christian Brueffer, Pia Leandersson, Lao H. Saal, Christer Borgfeldt
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Preoperative ctDNA Levels are Associated with Poor Overall Survival in Patients with Ovarian Cancer
805P Tumor-informed ctDNA detection as a predictive marker for postoperative residual disease in epithelial ovarian cancer: A feasibility study
Background
Complete tumor resection is the most relevant prognostic factor for overall survival in high grade serous ovarian cancer …
Christoph Grimm, Valentina Paspalj, Magdalena Postl, Lao H. Saal, Christian Brueffer, Nuria Segui Gracia, Miguel Alcaide, Stephan Polterauer, Lucia Oton, Yilun Chen, Gerda Hofstetter, Leonhard Müllauer
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805P Tumor-informed ctDNA detection as a predictive marker for postoperative residual disease in epithelial ovarian cancer: A feasibility study
#898 Tumor-informed ctDNA detection as a marker for postoperative residual disease in epithelial ovarian cancer – results of a feasibility study
Introduction/Background
Complete tumor resection is the most relevant prognostic factor for overall survival in high grade serous …
Magdalena Postl, Valentina Paspalj, Christian Brueffer, Nuria Segui Gracia, Miguel Alcaide, Lucia Oton, Yilun Chen, Lao H. Saal, Gerda Hofstetter, Leonhard Müllauer, Stephan Polterauer, Christoph Grimm
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#898 Tumor-informed ctDNA detection as a marker for postoperative residual disease in epithelial ovarian cancer – results of a feasibility study
Abstract 5710: Detection and monitoring of t(11;14) in liquid biopsies from patients with relapsed/refractory multiple myeloma treated with venetoclax-based regimens
Venetoclax (Ven) is a selective B-cell lymphoma 2 inhibitor being studied in t(11;14)+ relapsed/refractory multiple myeloma (MM). …
Xiaotong Li, Lao H. Saal, Christian Brueffer, Yilun Chen, Johanna Asklin, Saman Alvi, Srinivas Venkatram, Jeremy A. Ross
DOI
Abstract 5710: Detection and monitoring of t(11;14) in liquid biopsies from patients with relapsed/refractory multiple myeloma treated with venetoclax-based regimens
2022-RA-627-ESGO: Preoperative circulating tumor DNA level is associated to poor overall survival in patients with ovarian cancer
Introduction/Background
Circulating tumor DNA (ctDNA), which is shed from tumor cells into the blood, is a promising minimal-invasive …
Arturas Dobilas, Pia Leandersson, Yilun Chen, Miguel Alcaide, Christian Brueffer, Lao H. Saal, Christer Borgfeldt
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Clinical associations of ESR2 (estrogen receptor beta; ERβ) expression across thousands of primary breast tumors
Estrogen receptor alpha (ERα, encoded by ESR1) is a well-characterized transcription factor expressed in more than 75% of breast tumors …
Hina Dalal, Malin Dahlgren, Sergii Gladchuk, Christian Brueffer, Sofia K. Gruvberger-Saal, Lao H. Saal
DOI PDF Dataset
Clinical associations of ESR2 (estrogen receptor beta; ERβ) expression across thousands of primary breast tumors
Preexisting Somatic Mutations of Estrogen Receptor Alpha (ESR1) in Early-Stage Primary Breast Cancer
Background
More than three-quarters of primary breast cancers are positive for estrogen receptor alpha (ER; encoded by the gene ESR1), …
Malin Dahlgren, Anthony M. George, Christian Brueffer, Sergii Gladchuk, Yilun Chen, Johan Vallon-Christersson, Cecilia Hegardt, Jari Häkkinen, Lisa Rydén, Martin Malmberg, Christer Larsson, Sofia K. Gruvberger-Saal, Anna Ehinger, Niklas Loman, Åke Borg, Lao H. Saal
DOI PDF Dataset Press Release
Preexisting Somatic Mutations of Estrogen Receptor Alpha (ESR1) in Early-Stage Primary Breast Cancer